Casemiro's sending off for Manchester United vs Southampton, on Sunday afternoon, means Erik ten Hag will be without him for some important games.
United were back in Premier League action for the first time since being absolutely humiliated by rivals Liverpool the previous week, in a hammering.
They had returned to winning ways in the Europa League in midweek, with Wout Weghorst scoring his first goal at Old Trafford, but knew they needed to return to winning ways in the league.
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Ten Hag's men came up against bottom of the table Southampton, who won against a poor Leicester City the previous week for their second three points in three games.
Ten Hag went into the game with an attacking line up, pairing Bruno Fernandes with Casemiro in midfield, and a front four including Jadon Sancho, Antony, Marcus Rashford and Weghorst.
However, in the 34th minute, the Brazilian was shown his marching orders after a studs up challenge on Carlos Alcaraz, earning him an early bath.
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It was the second red of the season for the midfielder, equalling the amount of times he was sent off in nine years for Real Madrid.
With it being his second such card, it means that he'll miss four games through suspension, starting with next weekend's FA Cup tie with Fulham, which won't be affected by the Gary Lineker situation.
After that he is due to miss league games with Newcastle United, Brentford and Everton in the coming weeks, as the team attempt to lock down their top four position.
The 31-year-old could consider himself somewhat unlucky with the card, after his foot appeared to bounce off the ball, which he won, but it was a dangerous challenge still.
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He was clearly very emotional as he walked off the pitch, having to be consoled by teammate and countryman Antony, before heading down the tunnel.
Earlier in the season, the Brazilian was sent off at Old Trafford in a game against Crystal Palace, after raising his hands to Will Hughes' neck.
The midfielder also missed United's huge game with Arsenal earlier in the year, after reaching five yellow cards for the season, in the other fixture with Palace.
He has been an extremely important player for Ten Hag's side and proved himself worth every penny of the £60 million they spent of the five time Champions League winner last summer.
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Whilst he is suspended for domestic fixtures, Casemiro will still be available for the Europa League return game to Real Betis on Thursday night.
Featured Image Credit: Alamy/TwitterTopics: Casemiro, Manchester United, Premier League, FA Cup, Europa League