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Jesse Marsch's side had a strong opening game last weekend, defeating Wolves at Elland Road, while Ralph Hasenhüttl's men had a disappointing one, losing 4-1 to Spurs.
The Southampton manager expects another difficult game today against the visitors, stating to the media ahead of the clash:
“I think this is a very committed team with a similar style to what we play sometimes"
"I don’t want to say it is easy to prepare, but you know exactly what to expect."
Marsch is also expecting a tough fixture:
"I know that going down to Southampton won't be easy, that it's going to be very hot and that will be a factor in the match and so we have to manage that well."
Here's everything you need to know about the match.
Southampton vs Leeds won't be on traditional television as it is affected by the Saturday afternoon TV blackout.
However, fans will be able to watch highlights on BBC's Match of the Day on Saturday evening.
The game will kick-off at 3PM BST and will take place at St. Mary's Stadium.
Southampton are favourites to win the fixture, and have won four of their past five home league matches against Leeds.