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The last time these two teams met in North London the Saints came out as 3-2 winners.
Spurs will be without Oliver Skipp, who has an injury, and new signing Richarlison, who is serving the final match of his two-game ban for chucking a flare into the stand in Everton's win over Chelsea last season.
Southampton's Nathan Tella and Theo Walcott won't feature either, as they are also nursing injuries.
Here's everything you need to know about Tottenham vs Southampton.
The game won't shown live on TV in the UK, however fans can watch highlights on Match of the Day which will be broadcast at 10:20pm BST on BBC One and BBC iPlayer.
Tottenham v Southampton will kick off at 3pm BST and will take place at the Tottenham Hotspur Stadiumm which has a capacity of 62,850
Tottenham wins: 85
Southampton wins: 65
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