Charlie Austin's last-minute consolation goal turned £20 into £8.5k for one plucky Ladbrokes punter.
Having been 3-0 down away from home against Tottenham, Southampton's late goal meant all 20 Premier League sides found the net in one Gameweek for the first time in eight years.
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And that ensured an accumulator - roughly paying 420/1 - landed for several Ladbrokes punters, most notably a digital customer who placed £20 on the unlikely 10-fold.
Alex Apati of Ladbrokes said: "It's not the biggest win we've seen this season, but the way in which this acca landed will certainly take some beating. And if our plucky punter wasn't a Southampton fan before last night's game, they probably have a soft spot for Charlie Austin and co now!
Ladbrokes Latest Betting
BETSLIP IN FULL
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BOTH TEAMS TO SCORE 10-FOLD
Bournemouth v Huddersfield - 2-1
Brighton v Crystal Palace - 3-1
West Ham v Cardiff - 3-1
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Watford v Man City - 1-2
Burnley v Liverpool - 1-3
Everton v Newcastle - 1-1
Fulham v Leicester - 1-1
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Wolves v Chelsea - 2-1
Man United v Arsenal - 2-2
Tottenham v Southampton - 3-1
TOTAL STAKE - £20
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TOTAL RETURNS - £8,520.61